Free Energy Calculations in Rational Drug Design

Free Energy Calculations in Rational Drug Design

Free energy calculations represent the most accurate computational method available for predicting enzyme inhibitor binding affinities. Advances in computer power in the 1990s enabled the practical application of these calculations in rationale drug design. This book represents the first comprehensive review of this growing area of research and covers the basic theory underlying the method, numerous state of the art strategies designed to improve throughput and dozen examples wherein free energy calculations were used to design and evaluate potential drug candidates.

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Advanced Drug Formulation Design to Optimize Therapeutic Outcomes

Advanced Drug Formulation Design to Optimize Therapeutic Outcomes

This title demonstrates how advanced formulation designs and delivery technologies can be used to improve drug efficacy and treatment outcomes in particular therapeutic categories or disease states. It discusses nanoparticle systems for cancer treatments, and also presents cutting edge immono-regulation agents for transplantation and the local targeting of drugs, especially poorly water soluble drugs to provide enhanced therapeutic outcomes. In addition, this title highlights areas of therapy showing the most promise for improvement in clinical outcomes via advanced formulation design.

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Advanced Drug Design And Development: A Medicinal Chemistry Approach

Advanced Drug Design And Development: A Medicinal Chemistry Approach

This volume, entitled Advanced Drug Design and Development: A Medicinal Chemistry Approach, is a collection of lectures by most of the invited speakers in The Department of Pharmaceutical-Medicinal Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki.about the new trends in our science, through the presentations of renowned invited speakers. It is also aimed to create a forum for exchange of ideas in medicinal chemistry, in a different informal environment, bringing internationally recognized medicinal chemists closer to their Greek colleagues.

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Peptide-Based Drug Design: Methods and Protocols

Peptide-Based Drug Design: Methods and Protocols

Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular Biology™ series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.


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Pharmaceutical Experimental Design And Interpretation

Pharmaceutical Experimental Design And Interpretation


This complete revision of Understanding Experimental Design and Interpretation in Pharmaceutics provides a comprehensive and up-to-date guide for anyone involved in planning pharmaceutical experiments and analysing the results.After a brief discussion of the underlying statistical techniques, the major methods of experimental design and evaluation, such as multivariate analysis, principal components analysis and sequential analysis, are examined. A comprehensive review of factorial design, covering classical, partial and block designs, leads to a description of methods of optimization, including model-independent and model-dependent methods such as response surface methodology and multicriteria decision making. A separate chapter applies these methods to mixture designs which are particularly relevant to pharmaceutical formulations. Each chapter draws on real examples from the pharmaceutical industry making the book a practical aid for all pharmaceutical researchers.


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Smith and Williams' Introduction to the Principles of Drug Design and Action, Fourth Edition

Smith and Williams' Introduction to the Principles of Drug Design and Action, Fourth Edition
 
As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states. Smith and Williams' Introduction to the Principles of Drug Design and Action, 4th Edition provides a thorough introduction to the principles of rational drug design, including both novel and established approaches. The fourth edition of this popular textbook adopts a 'from the bench to the marketplace' approach, using real examples where possible. In addition to a comprehensive update of the previous edition, new advances in molecular techniques, biotechnological applications and computer-aided design have been added

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Pharmacy Practice

Pharmacy Practice


Today's pharmaceutical services are patient-oriented rather than drug-oriented. This shift towards patient-centred care comes at a time when healthcare is delivered by an integrated team of health workers. Effective pharmacy practice requires an understanding of the social context within which pharmacy is practised, recognising the particular needs and circumstances of the users of pharmaceutical services and of pharmacy's place within health service provision. Designed for undergraduate and postgraduate pharmacists, Pharmacy Practice provides a background to the social context of pharmacy including:
* the development of pharmacy practice
* international dimensions of pharmacy practice
* health, illness, and medicines use
* professional practice
* meeting the pharmaceutical care needs of specific populations
* measuring and regulating medicines use
* research methods, evaluation, audit and clinical governance



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Applied Pharmaceutical Practice

Applied Pharmaceutical Practice

This is a comprehensive guide through the main stages of pharmaceutical dispensing.The textbook is designed to guide student pharmacists or pharmacy technicians through the main stages involved in pharmaceutical dispensing. It provides students with a core reference text to accompany the compulsory dispensing course found in all pharmacy undergraduate programmes, highlighting and explaining all key concepts behind the processes involved in pharmaceutical dispensing.

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Public Relations for Pharmacists

Public Relations for Pharmacists


Equips pharmacy professionals with the tools necessary to advance their practice through public relations. The first book designed specifically for pharmacists, it explains how to work with the media; how to write news releases, public service announcements, and op-ed pieces; how to prepare for media interviews; how to work with PR agencies; and how to become involved in the community. The book contains lists of public relations do's and don'ts, points to consider, and tips for succeeding. Examples of successful PR activities and campaign and sample news release, public service announcement, op-ed article, and media pitch letter are also included.


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Pharmacy Student Survival Guide

Pharmacy Student Survival Guide


The book every pharmacy student must own!


Pharmacy Student Survival Guide is a one-of-a-kind roadmap for excelling in pharmacy practice courses. A combination calculations, kinetics, drug information, medical terminology, and laboratory data book all in one, the Guide helps you organize case information, improve problem-solving skills, learn terminology, and impress faculty during rounds.


Pharmacy Student Survival Guide is presented in three sections that span the entire pharmacy curriculum:


Systems and Expectations covering ethics, communication, monitoring drug therapy, and regulatory agencies, Patient Care Tool Box covering medical terminology, pharmacokinetics, laboratory data, and physical assessment, Topics in Pharmacy Practice covering Drug Information and Drug Literature Evaluation, Community/Ambulatory Care, Institutional Pharmacy Practice, Public Health, Reducing Health Disparities Through Domestic and Global Outreach to the Undeserved, Valuable for both introductory and advanced practice course, Pharmacy Student Survival Guide is a book you will turn to throughout your entire pharmacy education.


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Wilson & Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry 11th Ed.

Wilson & Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry 11th Ed.


Oregon State Univ., Corvallis. Blends the chemical and pharmaceutical principles necessary for understanding structure-activity relationships and molecular mechanisms of drug action. Offers new information on emerging trends and advances and the challenges posed by new diseases. Features a new chapter on combinatorial chemistry.


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