Pharmaceutics: The Science of Dosage Form Design

Pharmaceutics: The Science of Dosage Form Design

Edited by M. E. Aulton

A comprehensive textbook covering the design of dosage forms and all aspects of drug delivery systems. 'Pharmaceutics' in its broadest sense is the 'art of the apothecary' or, in simple terms, pharmaceutical preparations. It remains a diverse subject in the pharmacy curriculum, encompassing design of drugs, their manufacture, and the elimination of micro-organisms from the products. This books encompasses all those areas and pays particular attention to the design of dosage forms and their manufacture

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Textbook of Drug Design and Discovery

Textbook of Drug Design and Discovery

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine.

The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included

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Free Energy Calculations in Rational Drug Design

Free Energy Calculations in Rational Drug Design

Free energy calculations represent the most accurate computational method available for predicting enzyme inhibitor binding affinities. Advances in computer power in the 1990s enabled the practical application of these calculations in rationale drug design. This book represents the first comprehensive review of this growing area of research and covers the basic theory underlying the method, numerous state of the art strategies designed to improve throughput and dozen examples wherein free energy calculations were used to design and evaluate potential drug candidates.

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Advanced Drug Formulation Design to Optimize Therapeutic Outcomes

Advanced Drug Formulation Design to Optimize Therapeutic Outcomes

This title demonstrates how advanced formulation designs and delivery technologies can be used to improve drug efficacy and treatment outcomes in particular therapeutic categories or disease states. It discusses nanoparticle systems for cancer treatments, and also presents cutting edge immono-regulation agents for transplantation and the local targeting of drugs, especially poorly water soluble drugs to provide enhanced therapeutic outcomes. In addition, this title highlights areas of therapy showing the most promise for improvement in clinical outcomes via advanced formulation design.

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Advanced Drug Design And Development: A Medicinal Chemistry Approach

Advanced Drug Design And Development: A Medicinal Chemistry Approach

This volume, entitled Advanced Drug Design and Development: A Medicinal Chemistry Approach, is a collection of lectures by most of the invited speakers in The Department of Pharmaceutical-Medicinal Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki.about the new trends in our science, through the presentations of renowned invited speakers. It is also aimed to create a forum for exchange of ideas in medicinal chemistry, in a different informal environment, bringing internationally recognized medicinal chemists closer to their Greek colleagues.

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Peptide-Based Drug Design: Methods and Protocols

Peptide-Based Drug Design: Methods and Protocols

Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular Biology™ series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.


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Pharmaceutical Experimental Design And Interpretation

Pharmaceutical Experimental Design And Interpretation


This complete revision of Understanding Experimental Design and Interpretation in Pharmaceutics provides a comprehensive and up-to-date guide for anyone involved in planning pharmaceutical experiments and analysing the results.After a brief discussion of the underlying statistical techniques, the major methods of experimental design and evaluation, such as multivariate analysis, principal components analysis and sequential analysis, are examined. A comprehensive review of factorial design, covering classical, partial and block designs, leads to a description of methods of optimization, including model-independent and model-dependent methods such as response surface methodology and multicriteria decision making. A separate chapter applies these methods to mixture designs which are particularly relevant to pharmaceutical formulations. Each chapter draws on real examples from the pharmaceutical industry making the book a practical aid for all pharmaceutical researchers.


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Smith and Williams' Introduction to the Principles of Drug Design and Action, Fourth Edition

Smith and Williams' Introduction to the Principles of Drug Design and Action, Fourth Edition
 
As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states. Smith and Williams' Introduction to the Principles of Drug Design and Action, 4th Edition provides a thorough introduction to the principles of rational drug design, including both novel and established approaches. The fourth edition of this popular textbook adopts a 'from the bench to the marketplace' approach, using real examples where possible. In addition to a comprehensive update of the previous edition, new advances in molecular techniques, biotechnological applications and computer-aided design have been added

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