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A Handbook of Bioanalysis and Drug Metabolism

A Handbook of Bio-Analysis and Drug Metabolism

Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting until now.
A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drugdrug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills.

This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.

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Handbook of Drug Metabolism

Handbook of Drug Metabolism


Bringing together nearly forty collaborators from academic and industrial laboratories, this reference furnishes an overview of the subject from a historical, kinetic, and chemical context. A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabolism in drug discovery and development. Containing tables, drawings, photographs, and equations, it highlights the importance of pharmacokinetics and cytochrome P450, explains clearance, volume of distribution, sequential metabolism, and nonlinear kinetics, summarizes concepts of Phase 1 and 2 metabolites, evaluates tertiary amine metabolism and reactive metabolite chemistry, and more.

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Handbook of Drug Metabolism, Second Edition

Handbook of Drug Metabolism, Second Edition

This timely, expanded new edition is the definitive handbook for experienced drug metabolism and pharmaceutical scientists and those new to the field.
Written by internationally renowned authors, it provides integrated, comprehensive coverage of fundamental aspects of drug metabolism and the practical applications that help guide researchers through key challenges in modern drug discovery and development.

The Second Edition covers the many recent scientific and technical advances in the field, and is organized in four sections – ideal for use in undergraduate and graduate programs in Drug Metabolism and Clinical Pharmacology.

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Cosmetics Additives: An Industrial Guide

Cosmetics Additives: An Industrial Guide

Describes about 4000 cosmetics additives currently available for industrial use, compiled from information from 84 manufacturers and distributors. The cosmetics and personal care products industry has a $60 billion market worldwide, and future growth is expected. In the US the market breaks down roughly into: hair care-20%, fragrances-20%, skin care-14%, makeup-17%, deodorants and skin and body lotions-10%, and oral care products-10%. Growth is expected in products targeting ethnic markets and working women. The book lists the following product information, as available, in the manufacturer’s own words: (1) Company name and product category, (2) Trade name and product number, (3) Product description. Also included are a Trade Name Index and a list of Suppliers’ Addresses.

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Analysis of Cosmetic Products

Analysis of Cosmetic Products

Analysis of Cosmetic Products advises the reader from an analytical chemistry perspective on the choice of suitable analytical methods for production monitoring and quality control of cosmetic products. In the format of an easy-to-understand compendium of published literature on the subject, this book will enable people working in the cosmetic industry or in research laboratories to:

* become familiar with the main legislative and analytical literature on this subject and
* learn about and choose suitable analytical procedures for production monitoring and control of cosmetic products, according to their composition.

The first section of Analysis of Cosmetic Products covers various definitions and concepts relating to cosmetic products, current legislation in different countries and specific legislation on ingredients. The central body of the book addresses analytical methods for monitoring and quality control of cosmetic products with the fundamental objective being to enable reader's access to scientific reviews carried out by experts in analytical chemistry. The final section contains a small review of the alternative methods to using animals for cosmetic product evaluation.
* An essential resource for those in the cosmetic industry and research laboratories, allowing you to become familiar with the main analytical literature
* Up-to-date and exhaustive overviews of current knowledge dealing with cosmetic analysis, general concepts and legislation
* Including tables and figures, designed to graphically communicate important information in an easy-to-understand format

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Topical Absorption of Dermatological Products

Topical Absorption of Dermatological Products

Contains current methods of analysis for new formulations of cosmetics, perfumes, creams, and lotions! With contributions from world-renowned experts in the field, Topical Absorption of Dermatological Products summarizes · novel treatments for fungal nail infections · emerging risk assessment procedures for sunscreen products · real-time breath analysis and physiologically based pharmacokinetic modeling (PBPK) for the examination of chemically exposed tissues · the use of micelles, mixed micelles, liposomes, and microemulsions as effective drug delivery systems · modern therapeutic devices for the management of acute, subacute, and chronic steroid-responsive dermatoses Providing state-of-the-art strategies for the control of irritation and infection, Topical Absorption of Dermatological Products is an in-depth source for dermatologists, pharmacists, pharmacologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetics and toiletries, and upper-level undergraduate and graduate students in these disciplines.

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Cosmetic Formulation of Skin Care Products

Cosmetic Formulation of Skin Care Products

Specifically written to meet the needs of the cosmetic chemist and engineer, this reference outlines the latest technologies and issues pertinent to the development novel skin care products including advances in formulation and development, raw materials and active ingredients, compound testing, and clinical assessment. Organized by product category, then by body application area, this guide supplies all one needs to know to create effective skin care products for men and women in a diverse range of ethnic populations.

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Delivery System Handbook for Personal Care and Cosmetic Products : Technology, Applications and Formulations

Delivery System Handbook for Personal Care and Cosmetic Products : Technology, Applications and Formulations

Novel delivery systems designed to facilitate the use of “fountain of youth” and other functional actives is an idea whose time has come. In a rapidly growing global market eager for products that really work, accelerating market pull and technology push forces have set the stage for this Foundation text. This “must have” book is the first volume of a new series entitled “Breakthroughs in Personal Care and Cosmetic Technology.” It has been carefully designed for training, development, and the empowerment of synergistic technology transfer across the personal care, cosmetic, and pharmaceutical industries.
This book is intended to cause a breakthrough in effective communication and interaction among technology and marketing functions. It is a showcase for understanding, using, and marketing the technology of why and how delivery systems work, as well as current, emerging/potential applications and working formulations. Each chapter is written by one or more experts in the field. A wide range of companies serving the global marketplace are represented. These companies offer numerous types of delivery systems containing highly desirable functional actives, delivery system technology development services, and opportunities for technology licensing, mergers, and acquisitions. A unique feature of the book is the use of Mind Map™ technology to capture and present the essence of the inner-thinking of over 80 authors in a Book-at-a-Glance Executive Overview section. This section has been specifically designed to powerfully impact decision making leading to the development of innovative product differentiation in a global context.

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Dermatologic, Cosmeceutic, and Cosmetic Development: Therapeutic and Novel Approaches

Dermatologic, Cosmeceutic, and Cosmetic Development: Therapeutic and Novel Approaches

Recent advances in our understanding of the development and morphology of normal skin has led to improved methods to deliver therapeutic compounds to selected targeted areas both within the skin and systemically. This reference provides a clear overview of current pharmaceutical and cosmetic practices in the management of both major and minor skin disorders, and provides an expansive overview of novel drugs and therapies used to treat these conditions. Written for scientists interested in dermatological therapy and those concerned with the marketing for pharmaceutical and cosmetic products, this text will also prove useful for students developing strong research methods.

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Global Regulatory Issues for the Cosmetics Industry: Volume 1

Global Regulatory Issues for the Cosmetics Industry: Volume 1

The manufacture and use of cosmetics is an international undertaking unparalleled by any other industry. Regulation of this industry, however, is neither universal nor consistent. The purpose of this book (the first of a series) is to simplify the complex global Cosmetic Regulatory landscape by addressing the issues affecting the manufacture, packaging, and marketing of cosmetic products across the globe. Included are several chapters that examine the new European Union REACH regulation (Registration Evaluation and Authorization of CHemicals). Other chapters look at regulatory developments of individual countries, toxicity requirements, as well as how to develop a global regulatory strategy.

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SODEOPEC (Soaps, Detergents, and Oleochemicals)

SODEOPEC (Soaps, Detergents, and Oleochemicals)


This book contains updated material from some of the salient presentations at the Soaps, Detergents, and Oleochemicals (1997) and SODEOPEC (2002) conferences, including several new chapters. Like its two predecessors, Soap Technology for the 1990's and Soaps and Detergents: A Theoretical and Practical Review, this publication will be a valuable resource for those who are active in the increasingly interrelated and quickly changing fields of soaps, detergents, oleochemicals, and personal care products.


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Pharmaceutical Emulsions and Suspensions: Second Edition, Revised and Expanded

Pharmaceutical Emulsions and Suspensions: Second Edition, Revised and Expanded

University Montpellier, France. Covers fundamental and applied knowledge of emulsions and suspensions. Assists those working in all spheres of pharmacy in solving the problems posed by by emulsion and suspension formulations and applications. Diagrams, charts.

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Ophthalmic Drug Delivery Systems, Second Edition

Ophthalmic Drug Delivery Systems, Second Edition

Extensively revised and updated, this second edition compares conventional and innovative drug delivery systems. The book covers significant ophthalmic advances and breakthroughs in gene therapy, ocular microdialysis, vitreous drug disposition modelling, and receptor/transporter targeted drug delivery. It examines procedures in pharmacokinetic/pharmacodynamic modeling for the determination of appropriate dosing regimens, covers new developments in animal modeling, and discusses current regulations governing patenting, commercial product release, and human testing. This in-depth reference lays the groundwork for overcoming constraints on the delivery of ophthalmic drugs.

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Drug-Drug Interactions: Scientific and Regulatory Perspectives, Volume 43 (Advances in Pharmacology)

Drug-Drug Interactions: Scientific and Regulatory Perspectives, Volume 43 (Advances in Pharmacology)


Drug–Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug–drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug–drug interactions, the prediction of drug–drug interaction potential of new drugs, and the avoidance of clinically significant drug–drug interaction in patients.


Key Features


* Provides useful references on the science of drug-drug interactions
* Describes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpoint
* Contains original data from academic and industrial laboratories
* Presents an overview of regulatory agency positions


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Physicochemical Principles of Pharmacy, 4th Edition

Physicochemical Principles of Pharmacy, 4th Edition


Physical chemistry is the basis of rational pharmaceutical formulation and processing, and is fundamental to understanding the complexities of drug delivery and drug absorption. This textbook presents the physiochemical principles useful to the modern pharmaceutical scientist and pharmacist.


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Transporters as Targets for Drugs

Transporters as Targets for Drugs

Transporters are proteins which span the plasma membrane and regulate the traffic of small molecules in and out of the cell. Transporters play a particularly important role in chemical signalling between neurons in the CNS, where they act to control the concentration of neurotransmitters in the synapse. The majority of transporters which are actively being pursued as targets for drug discovery are CNS located and this reflects the history of the field which began with the tricyclic antidepressants (TCAs) over half a century ago. The use of transporter inhibition to regulate the synaptic concentrations of key neurotransmitters is an established approach in the discovery of psychiatric medications. This volume reviews advances in the field of transporters as targets for drug discovery in the last 10 years. The volume will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotech and academia. Following an overview chapter, seven chapters written by leading experts in their area reflect a range of topics pertinent to the transporter field. General topics include recent advances in the structural biology of transporters and its impact on potential structure based drug design and the design of ligands for Positron Emission Tomography and the importance of molecular imaging in understanding early clinical data. Medicinal chemistry approaches are described outlining the discovery of selective serotonin, noradrenaline and dopamine reuptake inhibitors, current efforts towards the discovery of mixed re-uptake inhibitors with varied ‘flavours’ of monoamine inhibition, advances in the development of inhibitors for the glycine transporter and the discovery of subtype selective EAAT inhibitors. In addition to being an interesting read, the reader will receive a critical overview of progress made in this rapidly developing field.

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Essentials of Pharmaceutical Chemistry, 3rd Edition

Essentials of Pharmaceutical Chemistry, 3rd Edition

It covers the core information required by pharmacy students to understand the action of modern drugs on the human body.The third edition is larger than the previous edition and includes a new chapter on licensing of drugs and medicines which describes the make up and function of important committees such as the Commission of Human Medicines and the British Pharmacopoeia Commission. This includes material that is within the public domain and explains the process of getting a drug to market.The majority of the chapters include more worked examples/tutorial examples and the chapter on Analytical spectroscopy has been updated to include "qualitative" spectroscopic methods especially NMR, mass spectroscopy and some IR and the chapter on Stability of drugs and medicines has been updated to include a major section on "prodrugs" which are inactive compounds designed to decompose within the body to release the active moiety.

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Drug Photochemistry and Stability

Drug Photochemistry and Stability

Presents the basic elements of the science, & serves as an excellent introduction to this emerging field of photochemistry. Detailed experimental conditions for photostability studies are given, along with a discussion of the recently implemented ICH Guidelines for drug photostability.

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Impurities Evaluation of Pharmaceuticals

Impurities Evaluation of Pharmaceuticals

Filling a gap in the pharmaceutical literature, this unique guide addresses the development of targeted methodologies to monitor impurities in pharmaceutical compounds and drug products. Furnishes physicochemical protocols to determine the purity of pharmaceutical compounds fully before pharmacological and toxicological studies begin! Providing a clear definition of the subject, Impurities Evaluation of Pharmaceuticals introduces various techniques for isolating and characterizing impurities presents guidelines to evaluate stability using kinetic studies shows how to develop stability-indicating methodologies details various methods that require minimal sample prepreparation gives regulatory perspectives on chiral impurities and more! Containing important literature citations and offering an invaluable list of applications, Impurities Evaluation of Pharmaceuticals is an outstanding resource for pharmacists and pharmacologists, clinical microbiologists, quality assurance and production managers in the pharmaceutical industry, analytical chemists and biochemists, pharmaceutical regulatory personnel, and upper-level undergraduate, graduate, and continuing-education students in these disciplines.

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Stockley's Drug Interactions 7th Edition

Stockley's Drug Interactions 8th Edition

Stockley's Drug Interactions, produced within the Martindale Editorial Team under Karen Baxter, remains the world's most comprehensive and authoritative reference book on drug interactions.
Contains detailed yet concise monographs

Covers interactions between therapeutic drugs, proprietary medicines, herbal medicines, foods, drinks, pesticides and some drugs of abuse

Based on published sources and fully referenced

A typical monograph contains a summary, clinical evidence for the interactions under discussion, the probable mechanism, clinical importance and management

Covers over 14,000 drug interactions

Contains over 2,800 monographs

Includes 17,600 references


Stockley's Drug Interactions provides the busy healthcare professional with quick and easy access to clinically relevant, evaluated and evidence-based information on drug interactions.

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Japanese Pharmacopoeia, 15th Edition

Japanese Pharmacopoeia
Fifteenth Edition (15th)

Publisher: Society of Japanese Pharmac
Number Of Pages: 1357
Publication Date: 2002-01
Sales Rank: 3114417
ISBN / ASIN: 4840806721
EAN: 9784840806725
Binding: Hardcover
Manufacturer: Society of Japanese Pharmacy
Studio: Society of Japanese Pharmacy

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The International Pharmacopoeia, Third Edition

The International Pharmacopoeia, Third Edition

Presents an historical account of the Pharmacopoeia and describes methods and procedures for the quality control of pharmaceutical substances and dosage forms, including a special section on quality control of anti-malarials.

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Pharmaceutical Microbiology

Pharmaceutical Microbiology

The textbook on `Pharmaceutical Microbiology` has been adequately developed and expanded according to the AICTE- Approved Syllabus-2000 meant for the Pharmacy Degree Programme across all the Indian Universities, and others abroad offering similar curricula.

Specific attention has been duly paid to the presentation of each chapter that essentially includes: brief introduction, theoretical aspects, classification, neat and vivid diagrammatic illustrations of figures-graphics-equipments, lucid explanations, supportive classical examples, and profusely supplemented with explanatory`foot notes`-references in addition to further reading bibliography.

The text content runs over ten chapters that may prove to be of paramount interest and enormous readability not only confined to the B.Pharm., students but also to various M.Sc., academic curricula in such disciplines as: Food Microbiology, Environmental Science, Microbiology etc.

Key Features IncludeConcise and exhaustive presentation of scientific informations from several sources.A wealth of theoretical information that opens newer possibilities.Detailed classification of various microbial aspects.Pharmaceutical assays and methodologies.Comprehensive index includes significant terminologies.Well documented statement of facts.



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tablet press

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Double layer tablet press machine

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TABLETS MAKING MACHINE

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Remington: The Science and Practice of Pharmacy

Remington: The Science and Practice of Pharmacy

For over 100 years, Remington has been the definitive textbook and reference on the science and practice of pharmacy. This Twenty-First Edition keeps pace with recent changes in the pharmacy curriculum and professional pharmacy practice. More than 95 new contributors and 5 new section editors provide fresh perspectives on the field. New chapters include pharmacogenomics, application of ethical principles to practice dilemmas, technology and automation, professional communication, medication errors, re-engineering pharmacy practice, management of special risk medicines, specialization in pharmacy practice, disease state management, emergency patient care, and wound care. Purchasers of this textbook are entitled to a new, fully indexed Bonus CD-ROM, affording instant access to the full content of Remington in a convenient and portable format.

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The Chronic Diseases, their Peculiar Nature and their Homeopathic Cure

The Chronic Diseases, their Peculiar Nature and their Homeopathic Cure.

The Chronic Diseases, their Peculiar Nature and their Homeopathic Cure.
by Dr Samuel Hahnemann


Translated from the second enlarged German edition of 1835, by Prof. Louis H. Tafel. With annotations by Richard Hughes, M. D., Edited by Pemberton Dudley, M. D.

Whatever estimate Science may finally place upon the discoveries and doctrines of Hahnemann, and whatever measure of confidence in his therapeutic belief Posterity may accord or withhold, his personality and work have achieved a position which must render them perpetually historic. His teachings have been so interwoven with the entire fabric of medical progress during the last hundred years, and are so interlaced with the formative development of the incoming century, that neither the wear and tear of time nor the dissections of criticism will ever be able to dissociate them. They are destined, inevitably, to run through the texture of every page in the future annals of medicine.

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Imagine Homeopathy: A Book of Experiments, Images, and Metaphors

Imagine Homeopathy: A Book of Experiments, Images, and Metaphors

In this unique book, homeopath Chris Kurz offers a highly effective and unique approach to learning and importantly, retaining, all of the important concepts of homeopathy. Using vivid analogies & informal language, Kurz emphasizes the importance of true insight rather than memory.

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Homeophaty-Like Cures like

Homeophaty-Like Cures like


Hadhrat Mirza Tahir Ahmad, 4th head of Ahmadiyya Muslim Community was also very well known around the globe for his excellent and unparallel expertise in the field of Homeopathy.

This is basically collection of those homeopathy lectures by Hadhrat Mirza Tahir Ahmad, 4th head of Ahmadiyya Muslim Community that are being broadcast on MTA (Muslim Television Ahmadiyya) and now are compiled in one book.

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Homeopathic Prescribing Pocket Companion

Homeopathic Prescribing Pocket Companion

This is a concise pocket book of clinical applications providing pharmacists with instant information for patients/customers.This concise pocket book offers all the basic information that a pharmacist will ever need regarding homeopathic remedies. Part one provides a general introduction on homoeopathy and the related disciplines of anthroposophy, Biochemic Salt and flower therapy. Part two includes decision tree prescribing flowcharts supported by supplementary information to assist in choosing the appropriate homeopathic medicine to treat a range of conditions. For the busy pharmacist who wants a useful hands-on pocket guide to homeopathy - this is the perfect book.

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Medicinal Chemistry of Bioactive Natural Products

Medicinal Chemistry of Bioactive Natural Products
Medicinal Chemistry of Bioactive Natural Products by: Xiao-Tian Liang, Wei-Shuo Fang.(Editors)
Publisher: Wiley ISBN: 0471660071 April 2006 Pages: 460 PDF 5.5 MB

Current discoveries and research into bioactive natural products Medicinal Chemistry of Bioactive natural products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents.

Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research.

Enhanced by examples with updated research results, the discussion covers such topics as:
* The chemistry and biology of epothilones
* Vancomycin and other glycopeptide antibiotic derivates
* Antitumor and other related activities of Taxol and its analogs
* The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin)
* Huperzine A: A natural drug for the treatment of Alzheimer's disease
* The medicinal chemistry of ginkgolides from Ginkgo biloba
* Recent progress in Calophyllum coumarins as potent anti-HIV agents
* Plant-derived anti-HIV agents and analogs
* Chemical synthesis of annonaceous acetogenins and their structurally modified mimics

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Contemporary Drug Synthesis

Drug Synthesis
Contemporary Drug Synthesis by: Jie Jack Li Douglas
Publisher: Wiley-Interscience ISBN: 0471214809 2004-06-25 Pages: 240 PDF 2.7 MB

An integrated and insightful look at successful drug synthesis in today’s drug discovery market
The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug.

Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry’s most respected scientists, this timely volume:

* Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others
* Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis
* Organizes the drugs into fourteen therapeutic areas for clarity and ease of use

Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry
students.


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