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Thursday, September 30, 2010

The Drugs and Cosmetics Act of India


The Drugs and Cosmetics Act of India

An Act to regulate the import, manufacture, distribution and sale of drugs 2[and cosmetics]; WHEREAS it is expedient to regulate the 3[import, manufacture, distribution and sale] of drugs 2[and cosmetics];

AND WHEREAS the Legislature of all the Provinces have passed resolutions in terms of section 103 of the Government of India Act, 1935 (26 Geo. 5, c.2), in relation to such of the above-mentioned matters and matters ancillary thereto as are enumerated in List II of the Seventh Schedule to the said Act.


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Tuesday, September 28, 2010

Topics in Stereochemistry, Volume 23 by Scott E. Denmark


Topics in Stereochemistry, Volume 23 by Scott E. Denmark
Publisher: Wiley-Interscience; 1 edition (January 24, 2003) ISBN: 0471176222 Pages: 392 PDF 4.82 MB

The chapters in this second Volume of the second era of Topics in Stereochemistry reflect the breadth of subdisciplines for which stereochemistry is of fundamental importance. I am particularly pleased that these chapters continue the precedent set by those in Volume 22 for their scholarship, timeliness and scope. The discovery and development of fullerenes created unprecedented opportunities in both fundamental and applied chemistry. Although the intrinsic chirality of the higher fullerene spheroids was recognized early on, the consequences of modification with chiral groups as well as substitution to create chiral structures have only been fully realized in recent years. The first chapter by Carlo Thilgen, Isabelle Gosse and Fran¸cois Diederich provides an insightful and thorough analysis of the origins of fullerene chirality complete with a systematic classification of structural types. Each family of chiral fullerenes is amply illustrated and discussed not only for the structural novelty but also potential applications. Now liberated from the confines of tetrahedral carbon, the fullerene molecules provide fascinating new scaffolds for chiral structures. This chapter exemplifies how the importance and consequences of chirality pervade all molecular science even as new universes of compounds are discovered.


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Sunday, September 26, 2010

Handbook of Heterocyclic Chemistry, Second Edition by Alan R. Katritzky


Handbook of Heterocyclic Chemistry, Second Edition by Alan R. Katritzky
Publisher: Academic Press; 2 edition (October 12, 2000) ISBN: 0080429882 Pages: 760 PDF 62.44 MB

Heterocyclic chemistry is the largest of the classical divisions of organic chemistry. Heterocyclic compounds are widely distributed in Nature, playing a vital role in the metabolism of living cells. Their practical applications range from extensive clinical use to fields as diverse as agriculture, photography, biocide formulation and polymer science. The range of known compounds is enormous, encompassing the whole spectrum of physical, chemical and biological properties.

This book provides a balanced, a concise and informative account of heterocyclic chemistry that will be suitable for graduate or advanced undergraduate students and a convenient reference book for research workers, for both specialists int he field and those whose expertise lies in other areas but who nevertheless need information on heterocylic chemistry. The Handbook of Heterocyclic Chemistry is illustrated throughout with thousands of clearly drawn chemical structures. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.


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Friday, September 17, 2010

Process Validation in Manufacturing of Biopharmaceuticals: Guidelines, Current Practices, and Industrial Case Studies


Process Validation in Manufacturing of Biopharmaceuticals: Guidelines, Current Practices, and Industrial Case Studies

A study of biopharmaceutical process validation. It aims to enable developers and producers to ensure safe products, reduce the risk of adverse reactions in patients, and avoid recalls by outlining sophisticated validation approaches to characterize processes, process intermediates, and final product fully. The text emphasizes cost effectiveness while determining what level of validation is required for different phases of development, license application, and process improvements.


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Essentials Of Human Physiology For Pharmacy


Essentials Of Human Physiology For Pharmacy
Publisher: CRC Press I Llc | ISBN: 0203495330 | edition 2004 | CHM | 384 pages | 1.54 mb

This textbook is designed to provide the fundamentals of human physiology to students of pharmacy and other health sciences. An important goal of this book is to enhance students’ perceptions of the relevance of physiology to pharmacy practice. The book includes important concepts in physiology described in sufficient detail so that the student may integrate and understand these principles and then be able to apply them in subsequent course-work in pharmacology and therapeutics. Furthermore, this text contains frequent and specific references to pharmacotherapeutics and the practice of pharmacy designed to facilitate students’ understanding of basic physiological concepts and their pertinence to their chosen profession.

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Ganong's Review of Medical Physiology



Review of Medical Physiology

For more than four decades, Ganong’s Review of Medical Physiology has been the leader in helping medical students and clinicians understand the fascinating subject of human and mammalian physiology. Concisely covering every important topic without sacrificing depth or readability, Ganong’s delivers more clinically-relevant, high-yield information per page than any similar text or review. You’ll find more than 600 full-color illustrations and text that strikes the perfect balance between detailed and concise.
Thoroughly updated to reflect the latest research and developments in important areas such as the cellular basis of neurophysiology, Ganong’s Review of Medical Physiology incorporates examples from clinical medicine throughout the chapters to illustrate important physiologic concepts. Whether you’re a student who needs an outstanding review for the USMLE or a physician who wants to keep pace with the ever-changing field of medical physiology, there’s no better place to turn than Ganong’s Review of Medical Physiology.

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Monday, September 6, 2010

Natural Products


Natural Products

Natural Products, Drug Discovery and Therapeutic Medicine timely shares the experience of renowned scientist from academy and industry working in the field. … a very comprehensive tool that will help everybody interested in the discovery of natural products. I highly recommend this book for those who want to understand the potential of drug development from natural products in the light of modern knowledge and technology as well as for individuals who want to understand history of pass successes in drug discovery from natural products.

This book addresses historical aspects of natural products and the integration of approaches to their discovery, microbial diversity, specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), specific sources (the sea, rainforest endophytes, and Ecuadorian biodiversity), and methodology (high-performance liquid chromatography profiling, combinatorial biosynthesis, genomics, bioinformatics, and strain improvement by modern genetic manipulations).
A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.


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Analysis of Drug Impurities


Analysis of Drug Impurities

This book is intended for student and practitioners alike and is structured to bring the relevant disciplines together in one reference book.

A key component of the quality of pharmaceutical drugs is the control of impurities. It is important to identify and quantify levels of impurities that may be present to provide safe, effective and well-controlled medicines.

The measurement and identification of impurities to today’s standards presents significant challenges to the analytical chemist. The development of modern quantitative methods is driven by these challenges, and the rapid development
of spectrometers has provided increasing opportunity to identify the structure, and therefore the origin and safety potential, of such impurities. This book provides a source of information for the analytical chemist to understand the challenges and the techniques available to permit accurate identification and quantification of drug impurities.
This is a unique book; the editors are to be conrgatulated on persuading their industrial colleagues to write chapters, providing an industrial focus on analytical issues. This is a useful volume which fills a gap in the literature… I would recommend the book to all process and analytical chemists.

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The Medical Basis of Psychiatry, 3rd edition


The Medical Basis of Psychiatry, 3rd edition
Stationary Office | Pages: 824 | 2008-05-16 | ISBN: 1588299171 | 18 MB

Psychiatry has emerged as a burgeoning scientific field with major advances in etiology and treatment of several disorders. Just as there was excitement in the anatomic advances that took place a hundred years ago when Emil Kraepelin and his collaborators took on the enormous task of classification of psychiatric disorders based on rational scientific thinking, new advances in genetics, biochemistry, neuroanatomy and pharmacotherapy of mental disorders have brought us even closer to a better understanding of complex disorders like schizophrenia, bipolar disorder, depression and even autism. The major goal of the previous edition of this classic book was to update the busy clinician, psychiatric resident and medical student with the most up-to-date information on etiology, diagnosis and treatment of psychiatric disorders. This goal remains the focus of the third edition of this book. In this updated and expanded edition, the reader is provided with the most contemporary information and literature supported by a close survey of the field. Several new chapters dealing with new concepts in biology and treatment of mental disorders have been added. This new edition of this classic title, with its focus on biologic and medical aspects of psychiatry, will continue to be of significant help to all interested in the scientific practice of psychiatry.


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Pharmaceutical Data Mining: Approaches and Applications for Drug Discovery


Pharmaceutical Data Mining: Approaches and Applications for Drug Discovery

In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, who address both the implementation of new data mining technologies and application issues in the industry. This accessible, comprehensive collection discusses important theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery—including chemogenomics, toxicogenomics, and individual drug response prediction. The five main sections of this volume cover:

* A general overview of the discipline, from its foundations to contemporary industrial applications
* Chemoinformatics-based applications
* Bioinformatics-based applications
* Data mining
methods in clinical development
* Data mining algorithms, technologies, and software tools, with emphasis on advanced algorithms and software that are currently used in the industry or represent promising approaches

In one concentrated reference, Pharmaceutical Data Mining reveals the role and possibilities of these sophisticated techniques in contemporary drug discovery and development. It is ideal for graduate-level courses covering pharmaceutical science, computational chemistry, and bioinformatics. In addition, it provides insight to pharmaceutical scientists, principal investigators, principal scientists, research directors, and all scientists working in the field of drug discovery and development and associated industries.


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